51 www.dnymladychinternistu.cz | 40. DNY MLADÝCH INTERNISTŮ OLOMOUC | 1.–2. června 2023 DIABETOLOGIE, ENDOKRINOLOGIE A PORUCHY METABOLISMU (2) – SEKCE 1 (Malá posluchárna PRAVÁ) Adiponectin / leptin ratio as an index to determine metabolic risk in patients after kidney transplantation Graňák K.1,2, Vnučák M.1,2, Beliančinová M.1,2, Kleinová P. 1,2, Pytliaková M.3, Dedinská I.1,2 1Transplant Centre, University Hospital Martin 2Department of Internal Medicine I, Jessenius Medical Faculty of Comenius University and University Hospital Martin 3Department of Gastrointestinal Internal Medicine, Jessenius Medical Faculty of Comenius University and University Hospital Martin Introduction: It has been confirmed that adiponectin / leptin (A/L) ratio correlates better with cardiometabolic risk factors than hormone levels alone. Based on the results in general population, A/L ratio > 1 can be considered normal, A/L ratio of 0.5 – 1 indicate a mode‑ rate increased risk and A/L ratio < 0.5 a severe increased cardiometabolic risk. The aim of our study was to determine the risk of developing post‑transplant diabetes mellitus (PTDM), pre‑ diabetes and other metabolic risk factors de‑ pending on A/L ratio in patients after kidney transplantation (KT). Material and methods: In the prospective analysis, the studied sample (n = 104) was divided into three groups: 1. cont‑ rol group, 2. patients who developed predia‑ betes and 3. patients who developed PTDM. Pretransplantation and at 3, 6 and 12 months after KT, we recorded the basic characteristics of the donor and recipient, including parame‑ ters reflecting graft function, metabolic and anthropometric parameters. At the same time, we monitored the levels of adipocytokines and calculated A/L ratio. Results: During the observed period, we recorded statistically significant increase in the A/L ratio in the control group (P = 0.0013), on the contrary, significant decrease in the PTDM group (P = 0.0003). Comparing the individual subgroups divided according to the values of A/L ratio in 1 year after KT, we found that patients with A/L ratio < 0.5 compared to those with a value > 1 were significantly longer in dialysis program, had higher BMI, waist circumference, poorer graft function, higher proportion of pre‑ diabetes and PTDM in 1 year after KT. We used significant variables in the multivariate analysis and using logistic regression we identified age at time of KT (OR 1.0709, P = 0.0337), triglycerides at 1 year (OR 2.7735, P = 0.0446) and A/L ratio < 0.5 as an independent risk factors for prediabe‑ tes and PTDM development 1 year after KT (OR 3.1724, P = 0.014). We found that the baseline A/L ratio was negatively correlated with BMI value (P = 0.0013) and A/L ratio 1 year after KT was negatively correlated with BMI (P = 0.0111), waist
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